In distribution networks with a high proportion of renewable energy sources (RES), classic methods of voltage regulation are not sufficient and cannot cope with rapid oscillations of production from such energy sources (primarily wind power plants and large photovoltaic power plants) and consequently rapid and unpredictable oscillations of voltage and power flows in to the network. For this reason, in such networks, in addition to classic management methods, it is necessary to actively include RES in voltage regulation and management of power flows in the distribution network. This paper describes the optimization algorithm for the coordinated management of RES connected to the medium voltage distribution network. Coordinated management of the production of working and reactive power of RES connected to the distribution network is carried out in such a way as to ensure the maximum evacuation of energy from RES and minimize losses of work power in the considered distribution network at a certain moment, while maintaining normal voltage conditions and avoiding overloading in the distribution network. After the description of the mathematical formulation of the proposed RES management method, a computer simulation was performed for five different calculation cases that were considered in this paper. The developed algorithm was applied to a modified IEEE 69-bus system on which different variants of RES operation control were tested.